Ontology highlight
ABSTRACT:
SUBMITTER: Poruchynsky MS
PROVIDER: S-EPMC4321245 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Poruchynsky Marianne S MS Komlodi-Pasztor Edina E Trostel Shana S Wilkerson Julia J Regairaz Marie M Pommier Yves Y Zhang Xu X Kumar Maity Tapan T Robey Robert R Burotto Mauricio M Sackett Dan D Guha Udayan U Fojo Antonio Tito AT
Proceedings of the National Academy of Sciences of the United States of America 20150120 5
The paradigm that microtubule-targeting agents (MTAs) cause cell death via mitotic arrest applies to rapidly dividing cells but cannot explain MTA activity in slowly growing human cancers. Many preferred cancer regimens combine a MTA with a DNA-damaging agent (DDA). We hypothesized that MTAs synergize with DDAs by interfering with trafficking of DNA repair proteins on interphase microtubules. We investigated nine proteins involved in DNA repair: ATM, ATR, DNA-PK, Rad50, Mre11, p95/NBS1, p53, 53B ...[more]