Ontology highlight
ABSTRACT:
SUBMITTER: Tian J
PROVIDER: S-EPMC4322367 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Tian Jie J Tian Chuan C Ding Yuehe Y Li Zhe Z Geng Qizhi Q Xiahou Zhikai Z Wang Jue J Hou Wenya W Liao Ji J Dong Meng-Qiu MQ Xu Xingzhi X Li Jing J
Scientific reports 20150210
Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurologic disorder caused by ATTCT expansion in the ATXN10 gene. Previous investigations have identified that depletion of Ataxin-10, the gene product, leads to cellular apoptosis and cytokinesis failure. Herein we identify the mitotic kinase Aurora B as an Ataxin-10 interacting partner. Aurora B interacts with and phosphorylates Ataxin-10 at S12, as evidenced by in vitro kinase and mass spectrometry analysis. Both endogenous and S ...[more]