Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC4322759 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20150201 2
Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase controlling many physiological processes in mammals. mTOR functions in two distinct protein complexes, namely mTORC1 and mTORC2. Compared to mTORC1, the specific roles of mTORC2 are less well understood. To investigate the potential contribution of mTORC2 to skeletal development and homeostasis, we have genetically deleted Rictor, an essential component of mTORC2, in the limb skeletogenic mesenchyme of th ...[more]