Ontology highlight
ABSTRACT:
SUBMITTER: Kuwabara WM
PROVIDER: S-EPMC4323339 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Kuwabara Wilson Mitsuo Tatagiba WM Zhang Liling L Schuiki Irmgard I Curi Rui R Volchuk Allen A Alba-Loureiro Tatiana Carolina TC
PloS one 20150210 2
Reactive oxygen species (ROS) primarily produced via NADPH oxidase play an important role for killing microorganisms in neutrophils. In this study we examined if ROS production in Human promyelocytic leukemia cells (HL60) differentiated into neutrophil-like cells (dHL60) induces ER stress and activates the unfolded protein response (UPR). To cause ROS production cells were treated with PMA or by chronic hyperglycemia. Chronic hyperglycemia failed to induce ROS production and did not cause activa ...[more]