Ontology highlight
ABSTRACT:
SUBMITTER: Haque N
PROVIDER: S-EPMC4323372 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Haque Nazmul N Kasim Noor Hayaty Abu NH Rahman Mohammad Tariqur MT
International journal of biological sciences 20150205 3
Mesenchymal stem cells (MSCs) are considered a potential tool for cell based regenerative therapy due to their immunomodulatory property, differentiation potentials, trophic activity as well as large donor pool. Poor engraftment and short term survival of transplanted MSCs are recognized as major limitations which were linked to early cellular ageing, loss of chemokine markers during ex vivo expansion, and hyper-immunogenicity to xeno-contaminated MSCs. These problems can be minimized by ex vivo ...[more]