Ontology highlight
ABSTRACT:
SUBMITTER: Malik HA
PROVIDER: S-EPMC4323382 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Chemical science 20140601 6
We outline a strategy to enable non-directed Pd(II)-catalyzed C-H functionalization in the presence of Lewis basic heterocycles. In a high-throughput screen of two Pd-catalyzed C-H acetoxylation reactions, addition of a variety of <i>N</i>-containing heterocycles is found to cause low product conversion. A pyridine-containing test substrate is selected as representative of heterocyclic scaffolds that are hypothesized to cause catalyst arrest. We pursue two approaches in parallel that allow produ ...[more]