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Overexpression of Csk-binding protein decreases growth, invasion, and migration of esophageal carcinoma cells by controlling Src activation.

ABSTRACT: To investigate the mechanisms by which Csk-binding protein (CBP) inhibits tumor progression in esophageal carcinoma.A CBP overexpressing esophageal carcinoma cell line (TE-1) was established. The growth, invasion, and migration of CBP-TE-1 cells, as well as the expression of Src were then determined and compared with those in normal TE-1 cells.The expression of Src was decreased by the overexpression of CBP in TE-1 cells. The growth, invasion, and migration of TE-1 cells were decreased by the overexpression of CBP.This study indicates that CBP may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src. CBP may be a potential tumor suppressor and targeting the CBP gene may be an alternative strategy for the development of therapies for esophageal carcinoma.

SUBMITTER: Zhou D

PROVIDER: S-EPMC4323457 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Overexpression of Csk-binding protein decreases growth, invasion, and migration of esophageal carcinoma cells by controlling Src activation.

Zhou Dong D Dong Peng P Li Yu-Min YM Guo Fa-Cai FC Zhang An-Ping AP Song Run-Ze RZ Zhang Ya-Min YM Li Zhi-Yong ZY Yuan Dong D Yang Chuan C

World journal of gastroenterology 20150201 6

<h4>Aim</h4>To investigate the mechanisms by which Csk-binding protein (CBP) inhibits tumor progression in esophageal carcinoma.<h4>Methods</h4>A CBP overexpressing esophageal carcinoma cell line (TE-1) was established. The growth, invasion, and migration of CBP-TE-1 cells, as well as the expression of Src were then determined and compared with those in normal TE-1 cells.<h4>Results</h4>The expression of Src was decreased by the overexpression of CBP in TE-1 cells. The growth, invasion, and migr ...[more]

PMID: 25684946

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