Ontology highlight
ABSTRACT:
SUBMITTER: Wende AR
PROVIDER: S-EPMC4323486 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Wende Adam R AR O'Neill Brian T BT Bugger Heiko H Riehle Christian C Tuinei Joseph J Buchanan Jonathan J Tsushima Kensuke K Wang Li L Caro Pilar P Guo Aili A Sloan Crystal C Kim Bum Jun BJ Wang Xiaohui X Pereira Renata O RO McCrory Mark A MA Nye Brenna G BG Benavides Gloria A GA Darley-Usmar Victor M VM Shioi Tetsuo T Weimer Bart C BC Abel E Dale ED
Molecular and cellular biology 20141222 5
Sustained Akt activation induces cardiac hypertrophy (LVH), which may lead to heart failure. This study tested the hypothesis that Akt activation contributes to mitochondrial dysfunction in pathological LVH. Akt activation induced LVH and progressive repression of mitochondrial fatty acid oxidation (FAO) pathways. Preventing LVH by inhibiting mTOR failed to prevent the decline in mitochondrial function, but glucose utilization was maintained. Akt activation represses expression of mitochondrial ...[more]