Ontology highlight
ABSTRACT:
SUBMITTER: Lutz L
PROVIDER: S-EPMC4323857 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Lutz Lindy L Okenka Genevieve G Schoelz James J Leisner Scott S
Virology 20141212
Cauliflower mosaic virus gene VI product (P6) is an essential protein that forms cytoplasmic, inclusion bodies (IBs). P6 contains four regions involved in self-association, termed D1-D4. D3 binds to D1, along with D4 and contains a spacer region (termed D3b) between two RNA-binding domains. Here we show D3b binds full-length P6 along with D1 and D4. Full-length P6s harboring single amino acid substitutions within D3b showed reduced binding to both D1 and D4. Full-length P6s containing D3b mutati ...[more]