Ontology highlight
ABSTRACT:
SUBMITTER: Stapels DA
PROVIDER: S-EPMC4323955 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Stapels Daphne A C DA Geisbrecht Brian V BV Rooijakkers Suzan H M SH
Current opinion in microbiology 20141118
Neutrophil serine proteases (NSPs) are critical for the effective functioning of neutrophils and greatly contribute to immune protection against bacterial infections. Thanks to their broad substrate specificity, these chymotrypsin-like proteases trigger multiple reactions that are detrimental to bacterial survival such as direct bacterial killing, generation of antimicrobial peptides, inactivation of bacterial virulence factors and formation of neutrophil extracellular traps. Recently, the impor ...[more]