Ontology highlight
ABSTRACT:
SUBMITTER: Ghanian Z
PROVIDER: S-EPMC4324470 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Ghanian Zahra Z Maleki Sepideh S Park SunYoung S Sorenson Christine M CM Sheibani Nader N Ranji Mahsa M
Journal of biophotonics 20130606 10
Hereditary Hemorrhagic Telangiectasia-1 (HHT-1) is a vascular disease caused by mutations in the endoglin (Eng)/CD105 gene. The objective of this study was to quantify the oxidative state of a rodent model of HHT-1 using an optical imaging technique. We used a cryofluorescence imaging instrument to quantitatively assess tissue metabolism in this model. Mitochondrial redox ratio (FAD/NADH), FAD RR, was used as a quantitative marker of the metabolic status and was examined in the kidneys, and eyes ...[more]