Ontology highlight
ABSTRACT:
SUBMITTER: Barakat TS
PROVIDER: S-EPMC4325229 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Stem cell reports 20150129 2
In placental mammals, balanced expression of X-linked genes is accomplished by X chromosome inactivation (XCI) in female cells. In humans, random XCI is initiated early during embryonic development. To investigate whether reprogramming of female human fibroblasts into induced pluripotent stem cells (iPSCs) leads to reactivation of the inactive X chromosome (Xi), we have generated iPSC lines from fibroblasts heterozygous for large X-chromosomal deletions. These fibroblasts show completely skewed ...[more]