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Emerging strategies for treating brain metastases from breast cancer.

ABSTRACT: Brain metastasis is an end stage in breast cancer progression. Traditional treatment options have minimal efficacy, and overall survival is on the order of months. The incidence of brain metastatic disease is increasing with the improved management of systemic disease and prolongation of survival. Unfortunately, the targeted therapies that control systemic disease have diminished efficacy against brain lesions. There are reasons to be optimistic, however, as emerging therapies have shown promise in preclinical and early clinical settings. This review discusses recent advances in breast cancer brain metastasis therapy and potential approaches for successful treatment.

SUBMITTER: Kodack DP

PROVIDER: S-EPMC4325273 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Emerging strategies for treating brain metastases from breast cancer.

Kodack David P DP Askoxylakis Vasileios V Ferraro Gino B GB Fukumura Dai D Jain Rakesh K RK

Cancer cell 20150201 2

Brain metastasis is an end stage in breast cancer progression. Traditional treatment options have minimal efficacy, and overall survival is on the order of months. The incidence of brain metastatic disease is increasing with the improved management of systemic disease and prolongation of survival. Unfortunately, the targeted therapies that control systemic disease have diminished efficacy against brain lesions. There are reasons to be optimistic, however, as emerging therapies have shown promise ...[more]

PMID: 25670078

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