Ontology highlight
ABSTRACT:
SUBMITTER: Lorberbaum T
PROVIDER: S-EPMC4325423 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Clinical pharmacology and therapeutics 20141220 2
Small molecule drugs are the foundation of modern medical practice, yet their use is limited by the onset of unexpected and severe adverse events (AEs). Regulatory agencies rely on postmarketing surveillance to monitor safety once drugs are approved for clinical use. Despite advances in pharmacovigilance methods that address issues of confounding bias, clinical data of AEs are inherently noisy. Systems pharmacology-the integration of systems biology and chemical genomics-can illuminate drug mech ...[more]