Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.
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ABSTRACT:
SUBMITTER: Jin L
PROVIDER: S-EPMC4325424 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.
Jin Lingtao L Li Dan D Alesi Gina N GN Fan Jun J Kang Hee-Bum HB Lu Zhou Z Boggon Titus J TJ Jin Peng P Yi Hong H Wright Elizabeth R ER Duong Duc D Seyfried Nicholas T NT Egnatchik Robert R DeBerardinis Ralph J RJ Magliocca Kelly R KR He Chuan C Arellano Martha L ML Khoury Hanna J HJ Shin Dong M DM Khuri Fadlo R FR Kang Sumin S
Cancer cell 20150201 2
How mitochondrial glutaminolysis contributes to redox homeostasis in cancer cells remains unclear. Here we report that the mitochondrial enzyme glutamate dehydrogenase 1 (GDH1) is commonly upregulated in human cancers. GDH1 is important for redox homeostasis in cancer cells by controlling the intracellular levels of its product alpha-ketoglutarate and subsequent metabolite fumarate. Mechanistically, fumarate binds to and activates a reactive oxygen species scavenging enzyme glutathione peroxidas ...[more]
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