Ontology highlight
ABSTRACT:
SUBMITTER: Ruan X
PROVIDER: S-EPMC4325468 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Ruan Xiangcai X Darwiche Sophie S SS Cai Changchun C Scott Melanie J MJ Pape Hans-Christoph HC Billiar Timothy R TR
Mediators of inflammation 20150129
Although tissue-derived high mobility group box 1 (HMGB1) is involved in many aspects of inflammation and tissue injury after trauma, its role in trauma-induced immune suppression remains elusive. Using an established mouse model of peripheral tissue trauma, which includes soft tissue and fracture components, we report here that treatment with anti-HMGB1 monoclonal antibody ameliorated the trauma-induced attenuated T-cell responses and accumulation of CD11b(+)Gr-1(+) myeloid-derived suppressor c ...[more]