Evolutionary forward genomics reveals novel insights into the genes and pathways dysregulated in recurrent early pregnancy loss.

ABSTRACT:

Study question

Are the genes that gained novel expression in the endometria of Eutherian (placental) mammals more likely to be dysregulated in patients with endometrial-associated recurrent early pregnancy loss (REPL)?

Summary answer

There was a significant enrichment of genes dysregulated in REPL patients among the Eutherian-specific endometrial genes.

What is known already

Pregnancy loss is the most common complication of human pregnancy. REPL has multiple etiologies, including dysregulation of endometrial function, leading to 'suboptimal' implantation. Although the implantation process is tightly regulated in Eutherian (placental) mammals, the molecular factors contributing to dysregulated endometrial gene expression patterns in women with REPL are largely unknown.

SUBMITTER: Kosova G 

PROVIDER: S-EPMC4325674 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature