Ontology highlight
ABSTRACT:
SUBMITTER: Marcott PF
PROVIDER: S-EPMC4325987 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Neuron 20140918 1
Striatal dopamine transmission underlies numerous goal-directed behaviors. Medium spiny neurons (MSNs) are a major target of dopamine in the striatum. However, as dopamine does not directly evoke a synaptic event in MSNs, the time course of dopamine signaling in these cells remains unclear. To examine how dopamine release activates D2-receptors on MSNs, G protein activated inwardly rectifying potassium (GIRK2; Kir 3.2) channels were virally overexpressed in the striatum, and the resulting outwar ...[more]