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T 1 relaxation measurement of ex-vivo breast cancer tissues at ultralow magnetic fields.

ABSTRACT: We investigated T 1 relaxations of ex-vivo cancer tissues at low magnetic fields in order to check the possibility of achieving a T 1 contrast higher than those obtained at high fields. The T 1 relaxations of fifteen pairs (normal and cancerous) of breast tissue samples were measured at three magnetic fields, 37, 62, and 122 ?T, using our superconducting quantum interference device-based ultralow field nuclear magnetic resonance setup, optimally developed for ex-vivo tissue studies. A signal reconstruction based on Bayesian statistics for noise reduction was exploited to overcome the low signal-to-noise ratio. The ductal and lobular-type tissues did not exhibit meaningful T 1 contrast values between normal and cancerous tissues at the three different fields. On the other hand, an enhanced T 1 contrast was obtained for the mucinous cancer tissue.

SUBMITTER: Lee SJ

PROVIDER: S-EPMC4326347 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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T 1 relaxation measurement of ex-vivo breast cancer tissues at ultralow magnetic fields.

Lee Seong-Joo SJ Shim Jeong Hyun JH Kim Kiwoong K Hwang Seong-Min SM Yu Kwon Kyu KK Lim Sanghyun S Han Jae Ho JH Yim Hyunee H Kim Jang-Hee JH Jung Yong Sik YS Kim Ku Sang KS

BioMed research international 20150129

We investigated T 1 relaxations of ex-vivo cancer tissues at low magnetic fields in order to check the possibility of achieving a T 1 contrast higher than those obtained at high fields. The T 1 relaxations of fifteen pairs (normal and cancerous) of breast tissue samples were measured at three magnetic fields, 37, 62, and 122 μT, using our superconducting quantum interference device-based ultralow field nuclear magnetic resonance setup, optimally developed for ex-vivo tissue studies. A signal rec ...[more]

PMID: 25705658

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