Ontology highlight
ABSTRACT:
SUBMITTER: Steeland S
PROVIDER: S-EPMC4326813 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Steeland Sophie S Puimège Leen L Vandenbroucke Roosmarijn E RE Van Hauwermeiren Filip F Haustraete Jurgen J Devoogdt Nick N Hulpiau Paco P Leroux-Roels Geert G Laukens Debby D Meuleman Philip P De Vos Martine M Libert Claude C
The Journal of biological chemistry 20141223 7
The cytokine TNF is a well known drug target for several inflammatory diseases such as Crohn disease. Despite the great success of TNF blockers, therapy could be improved because of high costs and side effects. Selective inhibition of TNF receptor (TNFR) 1 signaling holds the potential to greatly reduce the pro-inflammatory activity of TNF, thereby preserving the advantageous immunomodulatory signals mediated by TNFR2. We generated a selective human TNFR1 inhibitor based on Nanobody (Nb) technol ...[more]