Ontology highlight
ABSTRACT:
SUBMITTER: Ohshima N
PROVIDER: S-EPMC4326834 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Ohshima Noriyasu N Kudo Takahiro T Yamashita Yosuke Y Mariggiò Stefania S Araki Mari M Honda Ayako A Nagano Tomomi T Isaji Chiaki C Kato Norihisa N Corda Daniela D Izumi Takashi T Yanaka Noriyuki N
The Journal of biological chemistry 20141220 7
The known mammalian glycerophosphodiester phosphodiesterases (GP-PDEs) hydrolyze glycerophosphodiesters. In this study, two novel members of the mammalian GP-PDE family, GDE4 and GDE7, were isolated, and the molecular basis of mammalian GP-PDEs was further explored. The GDE4 and GDE7 sequences are highly homologous and evolutionarily close. GDE4 is expressed in intestinal epithelial cells, spermatids, and macrophages, whereas GDE7 is particularly expressed in gastro-esophageal epithelial cells. ...[more]