Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice.
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ABSTRACT:
SUBMITTER: Leibowitz BJ
PROVIDER: S-EPMC4327858 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice.
Leibowitz Brian J BJ Wei Liang L Zhang Lin L Ping Xiaochun X Epperly Michael M Greenberger Joel J Cheng Tao T Yu Jian J
Nature communications 20140318
The role of bone marrow (BM) and BM-derived cells in radiation-induced acute gastrointestinal (GI) syndrome is controversial. Here we use bone marrow transplantation (BMT), total body irradiation (TBI) and abdominal irradiation (ABI) models to demonstrate a very limited, if any, role of BM-derived cells in acute GI injury and recovery. Compared with WT BM recipients, mice receiving BM from radiation-resistant PUMA KO mice show no protection from crypt and villus injury or recovery after 15 or 12 ...[more]
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