Unlike bone, cartilage regeneration remains elusive.
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ABSTRACT:
SUBMITTER: Huey DJ
PROVIDER: S-EPMC4327988 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Publications
Unlike bone, cartilage regeneration remains elusive.
Huey Daniel J DJ Hu Jerry C JC Athanasiou Kyriacos A KA
Science (New York, N.Y.) 20121101 6109
Articular cartilage was predicted to be one of the first tissues to successfully be regenerated, but this proved incorrect. In contrast, bone (but also vasculature and cardiac tissues) has seen numerous successful reparative approaches, despite consisting of multiple cell and tissue types and, thus, possessing more complex design requirements. Here, we use bone-regeneration successes to highlight cartilage-regeneration challenges: such as selecting appropriate cell sources and scaffolds, creatin ...[more]
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