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Interaction of HLA-DRB1*1501 and TNF-Alpha in a Population-based Case-control Study of Multiple Sclerosis.


ABSTRACT: This study was conducted to determine whether single nucleotide polymorphisms (SNPs) in nine genes (human leukocyte antigen (HLA), T cell receptor beta (TCA receptor ?), tumor necrosis factor ? (TNF ?), tumor necrosis factor ? (TNF ?), apolipoprotein E (APOE), interleukin 7 receptor alpha chain (IL7RA) interleukin 2 receptor alpha chain (IL2RA) myelin basic protein (MBP) and vitamin D receptor (VDR)) associated with multiple sclerosis (MS) could be replicated in a population-based sample, and to determine if these associations are modified by presence of HLA DRB1*1501. DNA was available from 722 individuals (223 with MS and 499 controls) who participated in a population-based case-control study. Cases and controls were matched on ancestry, age, gender and geographic area. HLA DRB1*1501 risk allele (T) was confirmed in this population using a genotypic test, controlling for multiple comparisons. Examining the effect of each SNP in the presence or absence of the HLA DRB1*1501 risk allele identified significant associations with TNF ? -1031 (rs1799964) among those without the HLA risk allele. No additional interactions were significant in a cases-only analysis. Our results indicate that an interaction between SNPs in TNF ? and HLA DRB1*1501 may influence the risk of developing MS.

SUBMITTER: Williamson DM 

PROVIDER: S-EPMC4328031 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Interaction of <i>HLA-DRB1</i>*<i>1501</i> and <i>TNF-Alpha</i> in a Population-based Case-control Study of Multiple Sclerosis.

Williamson Dhelia M DM   Marrie Ruth Ann RA   Ashley-Koch Allison A   Satten Glen A GA  

Immunology and infectious diseases 20130901 1


This study was conducted to determine whether single nucleotide polymorphisms (SNPs) in nine genes (human leukocyte antigen (<i>HLA</i>), T cell receptor beta (<i>TCA receptor β</i>), tumor necrosis factor α (<i>TNF α</i>), tumor necrosis factor β (<i>TNF β</i>), apolipoprotein E (<i>APOE</i>), interleukin 7 receptor alpha chain (<i>IL7RA</i>) interleukin 2 receptor alpha chain (<i>IL2RA</i>) myelin basic protein (<i>MBP</i>) and vitamin D receptor (<i>VDR</i>)) associated with multiple sclerosi  ...[more]

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