Dataset Information

Surgery in the era of the 'omics revolution.

ABSTRACT:

Background

Surgery is entering a new phase with the revolution in genomic technology. Cheap, mass access to next-generation sequencing is now allowing the analysis of entire human genomes at the DNA and RNA level. These data sets are being used increasingly to identify the molecular differences that underlie common surgical diseases, and enable them to be stratified for patient benefit.

Methods

This article reviews the recent developments in the molecular biology of colorectal, oesophagogastric and breast cancer.

Results

The review specifically covers developments in genetic predisposition, next-generation sequencing studies, biomarkers for stratification, prognosis and treatment, and other 'omics technologies such as metabolomics and proteomics.