Ontology highlight
ABSTRACT:
SUBMITTER: Manfrini N
PROVIDER: S-EPMC4328749 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Manfrini Nicola N Trovesi Camilla C Wery Maxime M Martina Marina M Cesena Daniele D Descrimes Marc M Morillon Antonin A d'Adda di Fagagna Fabrizio F d'Adda di Fagagna Fabrizio F Longhese Maria Pia MP
EMBO reports 20141219 2
Eukaryotic cells respond to DNA double-strand breaks (DSBs) by activating a checkpoint that depends on the protein kinases Tel1/ATM and Mec1/ATR. Mec1/ATR is activated by RPA-coated single-stranded DNA (ssDNA), which arises upon nucleolytic degradation (resection) of the DSB. Emerging evidences indicate that RNA-processing factors play critical, yet poorly understood, roles in genomic stability. Here, we provide evidence that the Saccharomyces cerevisiae RNA decay factors Xrn1, Rrp6 and Trf4 reg ...[more]