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ABSTRACT:
SUBMITTER: Macegoniuk K
PROVIDER: S-EPMC4329584 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Macegoniuk Katarzyna K Dziełak Anna A Mucha Artur A Berlicki Łukasz Ł
ACS medicinal chemistry letters 20141211 2
Inhibitors of bacterial ureases are considered to be promising compounds in the treatment of infections caused by Helicobacter pylori in the gastric tract and/or by urealytic bacteria (e.g., Proteus species) in the urinary tract. A new, extended transition state scaffold, bis(aminomethyl)phosphinic acid, was successfully explored for the construction of effective enzyme inhibitors. A reliable methodology for the synthesis of phosphinate analogues in a three-component Mannich-type reaction was el ...[more]