Ontology highlight
ABSTRACT:
SUBMITTER: Kuhn CD
PROVIDER: S-EPMC4329729 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Kuhn Claus-D CD Wilusz Jeremy E JE Zheng Yuxuan Y Beal Peter A PA Joshua-Tor Leemor L
Cell 20150129 4
Transcription in eukaryotes produces a number of long noncoding RNAs (lncRNAs). Two of these, MALAT1 and Menβ, generate a tRNA-like small RNA in addition to the mature lncRNA. The stability of these tRNA-like small RNAs and bona fide tRNAs is monitored by the CCA-adding enzyme. Whereas CCA is added to stable tRNAs and tRNA-like transcripts, a second CCA repeat is added to certain unstable transcripts to initiate their degradation. Here, we characterize how these two scenarios are distinguished. ...[more]