Targeting Metal-Aβ Aggregates with Bifunctional Radioligand [¹¹C]L2-b and a Fluorine-18 Analogue [¹⁸F]FL2-b.

ABSTRACT: Interest in quantifying metal-Aβ species in vivo led to the synthesis and evaluation of [¹¹C]L2-b and [¹⁸F]FL2-b as radiopharmaceuticals for studying the metallobiology of Alzheimer's disease (AD) using positron emission tomography (PET) imaging. [¹¹C]L2-b was synthesized in 3.6% radiochemical yield (nondecay corrected, n = 3), >95% radiochemical purity, from the corresponding desmethyl precursor. [¹⁸F]FL2-b was synthesized in 1.0% radiochemical yield (nondecay corrected, n = 3), >99% radiochemical purity, from a 6-chloro pyridine precursor. Autoradiography experiments with AD positive and healthy control brain samples were used to determine the specificity of binding for the radioligands compared to [¹¹C]PiB, a kn

SUBMITTER: Cary BP 

PROVIDER: S-EPMC4329991 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature