Ontology highlight
ABSTRACT:
SUBMITTER: Ho TT
PROVIDER: S-EPMC4330338 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Ho Tsui-Ting TT Zhou Nanjiang N Huang Jianguo J Koirala Pratirodh P Xu Min M Fung Roland R Wu Fangting F Mo Yin-Yuan YY
Nucleic acids research 20141120 3
The CRISPR/Cas has been recently shown to be a powerful genome-editing tool in a variety of organisms. However, these studies are mainly focused on protein-coding genes. The present study aims to determine whether this technology can be applied to non-coding genes. One of the challenges for knockout of non-coding genes is that a small deletion or insertion generated by the standard CRISPR/Cas system may not necessarily lead to functional loss of a given non-coding gene because of lacking an open ...[more]