Ontology highlight
ABSTRACT:
SUBMITTER: Torres-Machorro AL
PROVIDER: S-EPMC4330366 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Torres-Machorro Ana Lilia AL Aris John P JP Pillus Lorraine L
Nucleic acids research 20150127 3
Catalytically active proteins with divergent dual functions are often described as 'moonlighting'. In this work we characterize a new, chromatin-based function of Lys20, a moonlighting protein that is well known for its role in metabolism. Lys20 was initially described as homocitrate synthase (HCS), the first enzyme in the lysine biosynthetic pathway in yeast. Its nuclear localization led to the discovery of a key role for Lys20 in DNA damage repair through its interaction with the MYST family h ...[more]