Ontology highlight
ABSTRACT:
SUBMITTER: Bartsch JC
PROVIDER: S-EPMC4330513 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20141015 4
Dopaminergic hyperfunction and N-methyl-D-aspartate receptor (NMDAR) hypofunction have both been implicated in psychosis. Dopamine-releasing drugs and NMDAR antagonists replicate symptoms associated with psychosis in healthy humans and exacerbate symptoms in patients with schizophrenia. Though hippocampal dysfunction contributes to psychosis, the impact of NMDAR hypofunction on hippocampal plasticity remains poorly understood. Here, we used an NMDAR antagonist rodent model of psychosis to invest ...[more]