Ontology highlight
ABSTRACT:
SUBMITTER: Ciferri C
PROVIDER: S-EPMC4330774 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Ciferri Claudio C Chandramouli Sumana S Donnarumma Danilo D Nikitin Pavel A PA Cianfrocco Michael A MA Gerrein Rachel R Feire Adam L AL Barnett Susan W SW Lilja Anders E AE Rappuoli Rino R Norais Nathalie N Settembre Ethan C EC Carfi Andrea A
Proceedings of the National Academy of Sciences of the United States of America 20150126 6
Human cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant patients and the leading viral cause of birth defects after congenital infection. The glycoprotein complexes gH/gL/gO and gH/gL/UL128/UL130/UL131A (Pentamer) are key targets of the human humoral response against HCMV and are required for HCMV entry into fibroblasts and endothelial/epithelial cells, respectively. We expressed and characterized soluble forms of gH/gL, gH/gL/gO, and Pentamer. Mass spectrometry an ...[more]