Ontology highlight
ABSTRACT:
SUBMITTER: Adams DW
PROVIDER: S-EPMC4331003 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Adams David William DW Wu Ling Juan LJ Errington Jeff J
The EMBO journal 20150107 4
To proliferate efficiently, cells must co-ordinate division with chromosome segregation. In Bacillus subtilis, the nucleoid occlusion protein Noc binds to specific DNA sequences (NBSs) scattered around the chromosome and helps to protect genomic integrity by coupling the initiation of division to the progression of chromosome replication and segregation. However, how it inhibits division has remained unclear. Here, we demonstrate that Noc associates with the cell membrane via an N-terminal amphi ...[more]