The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment.
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ABSTRACT:
SUBMITTER: Chen R
PROVIDER: S-EPMC4331492 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment.
Chen Rui R Xu Min M Nagati Jason S JS Hogg Richard T RT Das Alok A Gerard Robert D RD Garcia Joseph A JA
PloS one 20150217 2
Optimal stress signaling by Hypoxia Inducible Factor 2 (HIF-2) during low oxygen states or hypoxia requires coupled actions of a specific coactivator/lysine acetyltransferase, Creb binding protein (CBP), and a specific deacetylase, Sirtuin 1 (SIRT1). We recently reported that acetylation of HIF-2 by CBP also requires a specific acetyl CoA generator, acetate-dependent acetyl CoA synthetase 2 (ACSS2). In this study, we demonstrate that ACSS2/HIF-2 signaling is active not only during hypoxia, but a ...[more]
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