Ontology highlight
ABSTRACT:
SUBMITTER: de Nooij JC
PROVIDER: S-EPMC4331628 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
de Nooij Joriene C JC Simon Christian M CM Simon Anna A Doobar Staceyann S Steel Karen P KP Banks Robert W RW Mentis George Z GZ Bewick Guy S GS Jessell Thomas M TM
The Journal of neuroscience : the official journal of the Society for Neuroscience 20150201 7
Mechanoreception is an essential feature of many sensory modalities. Nevertheless, the mechanisms that govern the conversion of a mechanical force to distinct patterns of action potentials remain poorly understood. Proprioceptive mechanoreceptors reside in skeletal muscle and inform the nervous system of the position of body and limbs in space. We show here that Whirlin/Deafness autosomal recessive 31 (DFNB31), a PDZ-scaffold protein involved in vestibular and auditory hair cell transduction, is ...[more]