Evaluating methods for modeling epistasis networks with application to head and neck cancer.
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ABSTRACT:
SUBMITTER: Talluri R
PROVIDER: S-EPMC4332043 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Evaluating methods for modeling epistasis networks with application to head and neck cancer.
Talluri Rajesh R Shete Sanjay S
Cancer informatics 20150210 Suppl 2
Epistasis helps to explain how multiple single-nucleotide polymorphisms (SNPs) interact to cause disease. A variety of tools have been developed to detect epistasis. In this article, we explore the strengths and weaknesses of an information theory approach for detecting epistasis and compare it to the logistic regression approach through simulations. We consider several scenarios to simulate the involvement of SNPs in an epistasis network with respect to linkage disequilibrium patterns among the ...[more]
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