Ontology highlight
ABSTRACT:
SUBMITTER: Bauer CR
PROVIDER: S-EPMC4332149 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Bauer Christopher R CR Li Shuang S Siegal Mark L ML
Molecular systems biology 20150121 1
The concept of robustness in biology has gained much attention recently, but a mechanistic understanding of how genetic networks regulate phenotypic variation has remained elusive. One approach to understand the genetic architecture of variability has been to analyze dispensable gene deletions in model organisms; however, the most important genes cannot be deleted. Here, we have utilized two systems in yeast whereby essential genes have been altered to reduce expression. Using high-throughput mi ...[more]