Ontology highlight
ABSTRACT:
SUBMITTER: Willet AH
PROVIDER: S-EPMC4332253 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Willet Alaina H AH McDonald Nathan A NA Bohnert K Adam KA Baird Michelle A MA Allen John R JR Davidson Michael W MW Gould Kathleen L KL
The Journal of cell biology 20150201 4
In Schizosaccharomyces pombe, cytokinesis requires the assembly and constriction of an actomyosin-based contractile ring (CR). Nucleation of F-actin for the CR requires a single formin, Cdc12, that localizes to the cell middle at mitotic onset. Although genetic requirements for formin Cdc12 recruitment have been determined, the molecular mechanisms dictating its targeting to the medial cortex during cytokinesis are unknown. In this paper, we define a short motif within the N terminus of Cdc12 th ...[more]