Ontology highlight
ABSTRACT:
SUBMITTER: Lee HK
PROVIDER: S-EPMC4332545 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Lee Hee-Kyoung HK Zhang Liuyin L Smith Misty D MD White H Steve HS Bulaj Grzegorz G
ChemMedChem 20090301 3
Neurotensin (NT) is an endogenous neuropeptide involved in a variety of central and peripheral neuromodulatory effects. Herein we show the effects of site-specific glycosylation on the in vitro and in vivo pharmacological properties of this neuropeptide. NT analogues containing O-linked disaccharides (beta-melibiose and alpha-TF antigen) or beta-lactose units linked by a PEG(3) spacer were designed and chemically synthesized using Fmoc chemistry. For the latter analogue, Fmoc-Glu-(beta-Lac-PEG(3 ...[more]