Development of potent inhibitors of pyocyanin production in Pseudomonas aeruginosa.
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ABSTRACT:
SUBMITTER: Miller LC
PROVIDER: S-EPMC4332565 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Development of potent inhibitors of pyocyanin production in Pseudomonas aeruginosa.
Miller Laura C LC O'Loughlin Colleen T CT Zhang Zinan Z Siryaporn Albert A Silpe Justin E JE Bassler Bonnie L BL Semmelhack Martin F MF
Journal of medicinal chemistry 20150203 3
The development of new approaches for the treatment of antimicrobial-resistant infections is an urgent public health priority. The Pseudomonas aeruginosa pathogen, in particular, is a leading source of infection in hospital settings, with few available treatment options. In the context of an effort to develop antivirulence strategies to combat bacterial infection, we identified a series of highly effective small molecules that inhibit the production of pyocyanin, a redox-active virulence factor ...[more]
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