Ontology highlight
ABSTRACT:
SUBMITTER: Amey JS
PROVIDER: S-EPMC4332693 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
FEBS letters 20150127 5
We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin. We demonstrate that this channel has most likely arisen by adaptation (gene fission or duplication) of an invertebrate ancestral mono(hetero)meric channel. This is the only identifiable voltage-gated sodium channel homologue in the aphid genome(s), and the channel's novel selectivity ...[more]