Ontology highlight
ABSTRACT:
SUBMITTER: Hibar DP
PROVIDER: S-EPMC4332874 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Hibar Derrek P DP Stein Jason L JL Jahanshad Neda N Kohannim Omid O Hua Xue X Toga Arthur W AW McMahon Katie L KL de Zubicaray Greig I GI Martin Nicholas G NG Wright Margaret J MJ Weiner Michael W MW Thompson Paul M PM
Neurobiology of aging 20140827
The discovery of several genes that affect the risk for Alzheimer's disease ignited a worldwide search for single-nucleotide polymorphisms (SNPs), common genetic variants that affect the brain. Genome-wide search of all possible SNP-SNP interactions is challenging and rarely attempted because of the complexity of conducting approximately 10(11) pairwise statistical tests. However, recent advances in machine learning, for example, iterative sure independence screening, make it possible to analyze ...[more]