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Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice.

ABSTRACT: Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.

SUBMITTER: Gapp K

PROVIDER: S-EPMC4333222 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice.

Gapp Katharina K Jawaid Ali A Sarkies Peter P Bohacek Johannes J Pelczar Pawel P Prados Julien J Farinelli Laurent L Miska Eric E Mansuy Isabelle M IM

Nature neuroscience 20140413 5

Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring. ...[more]

PMID: 24728267

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