Ontology highlight
ABSTRACT:
SUBMITTER: Laroche-Clary A
PROVIDER: S-EPMC4333490 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
British journal of cancer 20150120 4
<h4>Background</h4>This study aimed to determine whether the BRCA1 haplotype was associated with trabectedin efficacy in soft-tissue sarcoma (STS) patients.<h4>Methods</h4>We analysed BRCA1 single-nucleotide polymorphisms (SNPs) in tumour specimens from 135 advanced STS patients enrolled in published phase 2 trials or in a compassionate-use programme of trabectedin. Forty-four advanced STS patients treated with doxorubicin and 85 patients with localised STS served as controls. The 6-month nonpro ...[more]