New genetic variants improve personalized breast cancer diagnosis.
Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC4333695 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
New genetic variants improve personalized breast cancer diagnosis.
Liu Jie J Page David D Peissig Peggy P McCarty Catherine C Onitilo Adedayo A AA Trentham-Dietz Amy A Burnside Elizabeth E
AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science 20140407
Recent large-scale genome-wide association studies (GWAS) have identified a number of new genetic variants associated with breast cancer. However, the degree to which these genetic variants improve breast cancer diagnosis in concert with mammography remains unknown. We conducted a case-control study and collected mammography features and 77 genetic variants which reflect the state of the art GWAS findings on breast cancer. A naïve Bayes model was developed on the mammography features and these g ...[more]
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