Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster.
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ABSTRACT:
SUBMITTER: Dobson AJ
PROVIDER: S-EPMC4333721 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster.
Dobson Adam J AJ Chaston John M JM Newell Peter D PD Donahue Leanne L Hermann Sara L SL Sannino David R DR Westmiller Stephanie S Wong Adam C-N AC Clark Andrew G AG Lazzaro Brian P BP Douglas Angela E AE
Nature communications 20150218
Animals bear communities of gut microorganisms with substantial effects on animal nutrition, but the host genetic basis of these effects is unknown. Here we use Drosophila to demonstrate substantial among-genotype variation in the effects of eliminating the gut microbiota on five host nutritional indices (weight, protein, lipid, glucose and glycogen contents); this includes variation in both the magnitude and direction of microbiota-dependent effects. Genome-wide association studies to identify ...[more]
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