Ontology highlight
ABSTRACT:
SUBMITTER: Nestor CE
PROVIDER: S-EPMC4334405 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Genome biology 20150204
<h4>Background</h4>The DNA methylation profiles of mammalian cell lines differ from those of the primary tissues from which they were derived, exhibiting increasing divergence from the in vivo methylation profile with extended time in culture. Few studies have directly examined the initial epigenetic and transcriptional consequences of adaptation of primary mammalian cells to culture, and the potential mechanisms through which this epigenetic dysregulation occurs is unknown.<h4>Results</h4>We de ...[more]