Dataset Information

Objective sleep structure and cardiovascular risk factors in the general population: the HypnoLaus Study.

ABSTRACT:

Study objectives

To evaluate the association between objective sleep measures and metabolic syndrome (MS), hypertension, diabetes, and obesity.

Design

Cross-sectional study.

Setting

General population sample.

Participants

There were 2,162 patients (51.2% women, mean age 58.4 ± 11.1).

Interventions

Patients were evaluated for hypertension, diabetes, overweight/obesity, and MS, and underwent a full polysomnography (PSG).

Measurements and results

PSG measured variables included: total sleep time (TST), percentage and time spent in slow wave sleep (SWS) and in rapid eye movement (REM) sleep, sleep efficiency and arousal index (ArI). In univariate analyses, MS was associated with decreased TST, SWS, REM sleep, and sleep efficiency, and increased ArI. After adjustment for age, sex, smoking, alcohol, physical activity, drugs that affect sleep and depression, the ArI remained significantly higher, but the difference disappeared in patients without significant sleep disordered breathing (SDB). Differences in sleep structure were also found according to the presence or absence of hypertension, diabetes, and overweight/obesity in univariate analysis. However, these differences were attenuated after multivariate adjustment and after excluding subjects with significant SDB.

Conclusions

In this population-based sample we found significant associations between sleep structure and MS, hypertension, diabetes, and obesity. However, these associations were cancelled after multivariate adjustment. We conclude that normal variations in sleep contribute little if any to MS and associated disorders.

SUBMITTER: Haba-Rubio J

PROVIDER: S-EPMC4335515 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Publications

Objective sleep structure and cardiovascular risk factors in the general population: the HypnoLaus Study.

Haba-Rubio José J Marques-Vidal Pedro P Andries Daniela D Tobback Nadia N Preisig Martin M Vollenweider Peter P Waeber Gérard G Luca Gianina G Tafti Mehdi M Heinzer Raphaël R

Sleep 20150301 3

<h4>Study objectives</h4>To evaluate the association between objective sleep measures and metabolic syndrome (MS), hypertension, diabetes, and obesity.<h4>Design</h4>Cross-sectional study.<h4>Setting</h4>General population sample.<h4>Participants</h4>There were 2,162 patients (51.2% women, mean age 58.4 ± 11.1).<h4>Interventions</h4>Patients were evaluated for hypertension, diabetes, overweight/obesity, and MS, and underwent a full polysomnography (PSG).<h4>Measurements and results</h4>PSG measu ...[more]

PMID: 25325467

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Project description:BackgroundWhile data from primary care suggest an insufficient control of vascular risk factors, little is known about vascular risk factor control in the general population. We therefore aimed to investigate the adoption of adequate risk factor control and its determinants in the general population free of cardiovascular disease (CVD).MethodsData from the Characteristics and Course of Heart Failure Stages A-B and Determinants of Progression (STAAB) Cohort Study, a population-based study of inhabitants aged 30 to 79 years from the general population of Würzburg (Germany), were used. Proportions of participants without established CVD meeting targets for risk factor control recommended by 2016 ESC guideline were identified. Determinants of the accumulation of insufficiently controlled vascular risk factors (three or more) were assessed.ResultsBetween December 2013 and April 2015, 1379 participants without CVD were included; mean age was 53.1 ± 11.9 years and 52.9% were female; 30.8% were physically inactive, 55.2% overweight, 19.3% current smokers. Hypertension, dyslipidemia, and diabetes mellitus were prevalent in 31.8%, 57.6%, and 3.9%, respectively. Treatment goals were not reached despite medication in 52.7% of hypertensive, in 37.3% of hyperlipidemic and in 44.0% of diabetic subjects. Insufficiently controlled risk was associated with male sex (OR 1.94, 95%CI 1.44-2.61), higher age (OR for 30-39 years vs. 70-79 years 4.01, 95%CI 1.94-8.31) and lower level of education (OR for primary vs. tertiary 2.15, 95%CI 1.48-3.11).ConclusionsIn the general population, prevalence of vascular risk factors was high. We found insufficient identification and control of vascular risk factors and a considerable potential to improve adherence to cardiovascular guidelines for primary prevention. Further studies are needed to identify and overcome patient- and physician-related barriers impeding successful control of vascular risk factors in the general population.

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Dataset Information

Objective sleep structure and cardiovascular risk factors in the general population: the HypnoLaus Study.

Study objectives

Design

Setting

Participants

Interventions

Measurements and results

Conclusions

Publications

Objective sleep structure and cardiovascular risk factors in the general population: the HypnoLaus Study.

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