Ontology highlight
ABSTRACT:
SUBMITTER: Clavreul A
PROVIDER: S-EPMC4335613 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Clavreul Anne A Montagu Angélique A Lainé Anne-Laure AL Tétaud Clément C Lautram Nolwenn N Franconi Florence F Passirani Catherine C Vessières Anne A Montero-Menei Claudia N CN Menei Philippe P
International journal of nanomedicine 20150212
Recently developed drug delivery nanosystems, such as lipid nanocapsules (LNCs), hold great promise for the treatment of glioblastomas (GBs). In this study, we used a subpopulation of human mesenchymal stem cells, "marrow-isolated adult multilineage inducible" (MIAMI) cells, which have endogenous tumor-homing activity, to deliver LNCs containing an organometallic complex (ferrociphenol or Fc-diOH), in the orthotopic U87MG GB model. We determined the optimal dose of Fc-diOH-LNCs that can be carri ...[more]